Institute of Mineral Research

Life Sciences - Health & Wellness

  • Home
  • Open Access
  • Mineral Elements
  • Conditions A-Z
  • Submissions
  • About Us

Silicon deprivation decreases collagen formation in wounds and bone, and ornithine transaminase enzyme activity in liver.

Biol Trace Elem Res. 2002 Dec;89(3):251-61

Authors: Seaborn CD, Nielsen FH

Abstract

We have shown that silicon (Si) deprivation decreases the collagen concentration in bone of 9-wk-old rats. Finding that Si deprivation also affects collagen at different stages in bone development, collagen-forming enzymes, or collagen deposition in other tissues would have implications that Si is important for both wound healing and bone formation. Therefore, 42 rats in experiment 1 and 24 rats in experiment 2 were fed a basal diet containing 2 or 2.6 microg Si/g, respectively, based on ground corn and casein, and supplemented with either 0 or 10 microg Si/g as sodium metasilicate. At 3 wk, the femur was removed from 18 of the 42 rats in experiment 1 for hydroxyproline analysis. A polyvinyl sponge was implanted beneath the skin of the upper back of each of the 24 remaining rats. Sixteen hours before termination and 2 wk after the sponge had been implanted, each rat was given an oral dose of 14C-proline (1.8 microCi/100 g body wt). The total amount of hydroxyproline was significantly lower in the tibia and sponges taken from Si-deficient animals than Si-supplemented rats. The disintegrations per minute of 14C-proline were significantly higher in sponge extracts from Si- deficient rats than Si-supplemented rats. Additional evidence of aberrations in proline metabolism with Si deprivation was that liver ornithine aminotransferase was significantly decreased in Si-deprived animals in experiment 2. Findings of an increased accumulation of 14C-proline and decreased total hydroxyproline in implanted sponges and decreased activity of a key enzyme in proline synthesis (liver ornithine aminotransferase) in Si-deprived animals indicates an aberration in the formation of collagen from proline in sites other than bone that is corrected by Si. This suggests that Si is a nutrient of concern in wound healing as well as bone formation.

PMID: 12462748 [PubMed – indexed for MEDLINE]

Related Articles

  • Effects of silicon on osteoblast activity and bone mineralization of MC3T3-E1 cells.
  • Soluble silica inhibits osteoclast formation and bone resorption in vitro.
  • Silicon Biochemistry

Filed Under: Journal Publications Tagged With: collagen, Silica, wound healing

SEARCH

Silicon Biochemistry

Silicon as an Essential Trace Element in Animal Nutrition
Author: Edith Muriel Carlisle
READ FULL ARTICLE HERE (PDF)

Published in 1899

The Physiological Role of Mineral Nutrients

Author: Loew, Oscar, b. 1844 Volume: no.18 Subject: Plant physiology; Plants Assimilation; Minerals Publisher: Washington : G.P.O. Year: 1899 Possible … Read this book online

Most Recent Posts

  • Update on Nutrients Involved in Maintaining Healthy Bone
  • Lithium as a Nutrient
  • Does Potassium Deficiency Contribute to Hypertension in Children and Adolescents?
  • Iodine deficiency: Clinical implications.

View by Category

  • Clinical Trials / Studies
  • Elements
  • Journal Publications
  • Open Access
  • Seawater
  • Elements
  • Open Access
  • Journal Publications
  • Clinical Trials / Studies
About Us
About Open Access
For Authors
Our Contributors and Partners
Contact
Privacy
Terms & Conditions

Copyright ©2014 - 2018 Institute of Mineral Research