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Protein Lipidation As a Regulator of Apoptotic Calcium Release: Relevance to Cancer.

Abstract
Calcium is a critical regulator of cell death pathways. One of the most proximal events leading to cell death is activation of plasma membrane and endoplasmic reticulum-resident calcium channels. A large body of evidence indicates that defects in this pathway contribute to cancer development. Although we have a thorough understanding of how downstream elevations in cytosolic and mitochondrial calcium contribute to cell death, it is much less clear how calcium channels are activated upstream of the apoptotic stimulus. Recently, it has been shown that protein lipidation is a potent regulator of apoptotic signaling. Although classically thought of as a static modification, rapid and reversible protein acylation has emerged as a new signaling paradigm relevant to many pathways, including calcium release and cell death. In this review, we will discuss the role of protein lipidation in regulating apoptotic calcium signaling with direct therapeutic relevance to cancer.

PMID: 28706877 PMCID: PMC5489567 DOI: 10.3389/fonc.2017.00138

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Filed Under: Journal Publications Tagged With: Calcium, Cancer

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Silicon as an Essential Trace Element in Animal Nutrition
Author: Edith Muriel Carlisle
READ FULL ARTICLE HERE (PDF)

Published in 1899

The Physiological Role of Mineral Nutrients

Author: Loew, Oscar, b. 1844 Volume: no.18 Subject: Plant physiology; Plants Assimilation; Minerals Publisher: Washington : G.P.O. Year: 1899 Possible … Read this book online

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