Authors: Deckers IA, van den Brandt PA, van Engeland M, Soetekouw PM, Baldewijns MM, Goldbohm RA, Schouten LJ
Citation: Br. J. Cancer 2014 Feb;110(3):797-801
PMID : 24327014, Journal: Br. J. Cancer, 110, 3
Date created: 2014-02-05
Abstract
BACKGROUND: As sodium, potassium and fluid intake are related to hypertension, an established risk factor for renal cell cancer (RCC), they may be independent risk factors for RCC.
METHODS: The Netherlands Cohort Study (NLCS) with case-cohort design included 120,852 participants aged 55-69 years. At baseline, diet and lifestyle were assessed with questionnaires. After 17.3 years of follow-up, 485 RCC cases and 4438 subcohort members were available for analyses.
RESULTS: Sodium intake increased RCC risk (P-trend=0.03), whereas fluid and potassium intake did not. For high sodium and low fluid intake, the RCC risk additionally increased (P-interaction=0.02).
CONCLUSION: Sodium intake is a potential risk factor for RCC, particularly if fluid consumption is low.