Correlation of magnesium intake with metabolic parameters, depression and physical activity in elderly type 2 diabetes patients: a cross-sectional study
Nutrition Journal 2012, 11:41 doi:10.1186/1475-2891-11-41
The electronic version of this article is the complete one and can be found online at:http://www.nutritionj.com/content/11/1/41
© 2012 Huang et al.; licensee BioMed Central Ltd.
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Type 2 diabetes mellitus is a major global public health problem in the worldwide and is increasing in aging populations. Magnesium intake may be one of the most important factors for diabetes prevention and management. Low magnesium intake may exacerbate metabolic abnormalities. In this study, the relationships of magnesium intake with metabolic parameters, depression and physical activity in elderly patients with type 2 diabetes were investigated.
This cross-sectional study involved 210 type 2 diabetes patients aged 65 years and above. Participants were interviewed to obtain information on lifestyle and 24-hour dietary recall. Assessment of depression was based on DSM-IV criteria. Clinical variables measured included anthropometric measurements, blood pressure, and biochemical determinations of blood and urine samples. Linear regression was applied to determine the relationships of magnesium intake with nutritional variables and metabolic parameters.
Among all patients, 88.6% had magnesium intake which was less than the dietary reference intake, and 37.1% had hypomagnesaemia. Metabolic syndromes and depression were associated with lower magnesium intake (p < 0.05). A positive relationship was found between magnesium intake and HDL-cholesterol (p = 0.005). Magnesium intake was inversely correlated with triglyceride, waist circumference, body fat percent and body mass index (p < 0.005). After controlling confounding factor, HDL-cholesterol was significantly higher with increasing quartile of magnesium intake (p for trend = 0005). Waist circumference, body fat percentage, and body mass index were significantly lower with increase quartile of magnesium intake (p for trend < 0.001). The odds of depression, central obesity, high body fat percentage, and high body mass index were significantly lower with increasing quartile of magnesium intake (p for trend < 0.05). In addition, magnesium intake was related to high physical activity level and demonstrated lower serum magnesium levels. Serum magnesium was not significantly associated with metabolic parameters.
The majority of elderly type 2 diabetes who have low magnesium intake may compound this deficiency with metabolic abnormalities and depression. Future studies should determine the effects of increased magnesium intake or magnesium supplementation on metabolic control and depression in elderly people with type 2 diabetes.
- Wild S, Roglic G, Green A, Sicree R, King H: Global prevalence of diabetes: estimates for the year 2000 and projections for 2030.
- Meneilly GS, Tessier D: Diabetes in elderly adults.
- Huang ES, Liu JY, Moffet HH, John PM, Karter AJ: Glycemic control, complications, and death in older diabetic patients the diabetes and aging study.
- de Boer IH, Katz R, Cao JJ, Fried LF, Kestenbaum B, Mukamal K, et al.: Cystatin C, albuminuria, and mortality among older adults with diabetes.
- Moran A, Palmas W, Field L, Bhattarai J, Schwartz JE, Weinstock RS, et al.: Cardiovascular autonomic neuropathy is associated with microalbuminuria in older patients with type 2 diabetes.
- Rizvi AA: Management of diabetes in older adults.
- Rodriguez-Moran M, Guerrero-Romero F: Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial.
- Dong JY, Xun P, He K, Qin LQ: Magnesium intake and risk of type 2 diabetes: meta-analysis of prospective cohort studies.
- Swaminathan R: Magnesium metabolism and its disorders.
- Nadler JL, Buchanan T, Natarajan R, Antonipillai I, Bergman R, Rude R: Magnesium deficiency produces insulin resistance and increased thromboxane synthesis.
- Bohl CH, Volpe SL: Magnesium and exercise.
- Nielsen FH, Milne DB, Klevay LM, Gallagher S, Johnson L: Dietary magnesium deficiency induces heart rhythm changes, impairs glucose tolerance, and decreases serum cholesterol in post menopausal women.
- Barragan-Rodriguez L, Rodriguez-Moran M, Guerrero-Romero F: Depressive symptoms and hypomagnesemia in older diabetic subjects.
- McKeown NM, Jacques PF, Zhang XL, Juan W, Sahyoun NR: Dietary magnesium intake is related to metabolic syndrome in older Americans.
- Corica F, Corsonello A, Ientile R, Cucinotta D, Di Benedetto A, Perticone F, et al.: Serum ionized magnesium levels in relation to metabolic syndrome in type 2 diabetic patients.
- Guerrero-Romero F, Rodriguez-Moran M: Hypomagnesemia is linked to low serum HDL-cholesterol irrespective of serum glucose values.
- Corica F, Allegra A, Di Benedetto A, Giacobbe MS, Romano G, Cucinotta D, et al.: Effects of oral magnesium supplementation on plasma lipid concentrations in patients with non-insulin-dependent diabetes mellitus.
Magnes Res 1994, 7(1):43-47. PubMed Abstract
- Motoyama T, Sano H, Fukuzaki H: Oral magnesium supplementation in patients with essential hypertension.
- Finstad EW, Newhouse IJ, Lukaski HC, McAuliffe JE, Stewart CR: The effects of magnesium supplementation on exercise performance.
- Barragan-Rodriguez L, Rodriguez-Moran M, Guerrero-Romero F: Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial.
- Ismail Y, Ismail AA, Ismail AAA: The underestimated problem of using serum magnesium measurements to exclude magnesium deficiency in adults; a health warning is needed for “normal” results.
Clin Chem Lab Med 2010, 48(3):323-327. PubMed Abstract
- Arnaud MJ: Update on the assessment of magnesium status.
- Sales CH, Pedrosa LF, Lima JG, Lemos TM, Colli C: Influence of magnesium status and magnesium intake on the blood glucose control in patients with type 2 diabetes.
- Thompson FE, Byers T: Dietary assessment resource manual.
- Volpe SL: Magnesium, the metabolic syndrome, insulin resistance, and type 2 diabetes mellitus.
- American Diabetes Association: Report of the expert committee on the diagnosis and classification of diabetes mellitus.
Diabetes Care 1997, 20:1183-1197. PubMed Abstract
- American Diabetes Association: Standards of medical care in diabetes–2010.
- Kurukulasuriya LR, Sowers JR: Therapies for type 2 diabetes: lowering HbA1c and associated cardiovascular risk factors.
- Grundy SM, Cleeman JI, Merz CN, Brewer HB, Clark LT, Hunninghake DB, et al.: Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines.
- Xu J, Eilat-Adar S, Loria CM, Howard BV, Fabsitz RR, Begum M, et al.: Macronutrient intake and glycemic control in a population-based sample of American Indians with diabetes: the Strong Heart Study.
- Posner BM, Smigelski C, Duggal A, Morgan IL, Cobb I, Cupples LA: Validation of two-dimensional models for estimation of portion size in nutrition research.
J Am Diet Assoc 1992, 92:738-741. PubMed Abstract
- Huang MC, Hsu CC, Wang HS, Shin SJ: Prospective randomized controlled trial to evaluate effectiveness of registered dietitian-led diabetes management on glycemic and diet control in a primary care setting in Taiwan.
- Institute of Medicine, Food and Nutrition Board: Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D and fluoride. National Academy Press, Washington, D.C; 1997:71-145.
- Evans WJ: Protein nutrition, exercise and aging.
J Am Coll Nutr 2004, 23(6 Suppl):601S-609S. PubMed Abstract
- Hu G, Jousilahti P, Barengo NC, Qiao Q, Lakka TA, Tuomilehto J: Physical activity, cardiovascular risk factors, and mortality among Finnish adults with diabetes.
- Sahota PK, Knowler WC, Looker HC: Depression, diabetes, and glycemic control in an American Indian community.
- Hwang LC, Chen SC, Tjung JJ, Chiou HY, Chen CJ, Tsai CH: Body mass index as a predictor of mortality in older people in Taiwan.
International Journal of Gerontology 2009, 3(1):39-46. Publisher Full Text
- Monami M, Lamanna C, Balzi D, Bartalucci F, Melani C, Masotti G, et al.: Metabolic syndrome and cardiovascular mortality in older type 2 diabetic patients: a longitudinal study.
- Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO, Criqui M, Alexander RW, Anderson JL, Cannon RO, Criqui M, et al.: Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association.
- Levin A, Hemmelgarn B, Culleton B, Tobe S, McFarlane P, Ruzicka M, et al.: Guidelines for the management of chronic kidney disease.
- Wang JL, Weng YL, Pan WH, Kao MD: Trends and nutritional status for magnesium in Taiwan from NAHSIT 1993 to 2008.
Asia Pac J Clin Nutr 2011, 20(2):266-274. PubMed Abstract
- Moshfegh AJ, Goldman JD, Ahuja JK, Rhodes DG, LaComb RP: What We Eat in America, NHANES 2005–2006: Usual nutrient intakes from food and water compared to 1997 dietary reference intakes for vitamin D, calcium, phosphorus, and magnesium (24-page report). Agricultural Research Service, US Department of Agriculture; 2009. PubMed Abstract |Publisher Full Text
- Mirmiran P, Shab-Bidar S, Hosseini-Esfahani F, Asghari G, Hosseinpour-Niazi S, Azizi F:Magnesium intake and prevalence of metabolic syndrome in adults: tehran lipid and glucose study.
- Ustun TB, Ayuso-Mateos JL, Chatterji S, Mathers C, Murray CJ: Global burden of depressive disorders in the year 2000.
- Katon W, Schulberg H: Epidemiology of depression in primary care.
- Ali S, Stone MA, Peters JL, Davies MJ, Khunti K: The prevalence of co-morbid depression in adults with Type 2 diabetes: a systematic review and meta-analysis.
- Black SA: Increased health burden associated with comorbid depression in older diabetic Mexican Americans. Results from the hispanic established population for the epidemiologic study of the elderly survey.
- Pham PC, Pham PM, Pham SV, Miller JM, Pham PT: Hypomagnesemia in patients with type 2 diabetes.
- Nasri H, Baradaran HR: Lipids in association with serum magnesium in diabetes mellitus patients.
- Dominguez LJ, Barbagallo M, Lauretani F, Bandinelli S, Bos A, Corsi AM, et al.: Magnesium and muscle performance in older persons: the InCHIANTI study.
- Nielsen FH, Lukaski HC: Update on the relationship between magnesium and exercise.
- Rayssiguier Y, Guezennec CY, Durlach J: New experimental and clinical data on the relationship between magnesium and sport.
Magnes Res 1990, 3(2):93-102. PubMed Abstract
- McDonald R, Keen CL: Iron, zinc and magnesium nutrition and athletic performance.